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Targeted Allele Detail
Symbol: Ndrg2tm1Kmori
Name: N-myc downstream regulated gene 2; targeted mutation 1, Kazuhiro Morishita
MGI ID: MGI:5617965
Synonyms: NDRG2-
Gene: Ndrg2  Location: Chr14:51905271-51914004 bp, - strand  Genetic Position: Chr14, 26.72 cM
Ndrg2tm1Kmori/Ndrg2+ mice are susceptible to tumour formation

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:210264
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA lacZ-pA-neo-pA cassette was inserted into exon 2. Western blot analysis confirmed the absence of protein expression in the brains from homozygous mice. (J:210264)
Generation of Ndrg2tm1Kmori allele
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ndrg2 Mutation:  2 strains or lines available
Original:  J:210264 Nakahata S, et al., Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory