Hsph1^tm1Kzn
Targeted Allele Detail

Summary

• Symbol: Hsph1^tm1Kzn
• Name: heat shock 105kDa/110kDa protein 1; targeted mutation 1, Kazuhiro Nagata
• MGI ID: MGI:5617737
• Gene: Hsph1 Location: Chr5:149537752-149559841 bp, - strand Genetic Position: Chr5, 89.18 cM
• Alliance: Hsph1^tm1Kzn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:218516
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced the first exon via homologous recombination. Western blot analysis confirmed the absence of protein expression in brain lysates from homozygous mice. (J:218516)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hsph1 Mutation: 51 strains or lines available

References

• Original: J:218516 Nakamura J, et al., Targeted disruption of Hsp110/105 gene protects against ischemic stress. Stroke. 2008 Oct;39(10):2853-9
• All: 2 reference(s)