Clec12a^tm1Jrld
Targeted Allele Detail

Summary

• Symbol: Clec12a^tm1Jrld
• Name: C-type lectin domain family 12, member a; targeted mutation 1, Jurgen Ruland
• MGI ID: MGI:5617391
• Synonyms: Clec12a^-
• Gene: Clec12a Location: Chr6:129327207-129342266 bp, + strand Genetic Position: Chr6, 63.26 cM
• Alliance: Clec12a^tm1Jrld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210326
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A genomic fragment containing the first 2 exons, encoding the intracellular and transmembrane domain, was replaced with a neo cassette. Immunoblot analysis confirmed the absence of protein in the bone marrow of homozygous mutant mice. (J:210326)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec12a Mutation: 23 strains or lines available

References

• Original: J:210326 Neumann K, et al., Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Immunity. 2014 Mar 20;40(3):389-99
• All: 4 reference(s)