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Or8a1tm41(Drd1)Mom
Targeted Allele Detail
Summary
Symbol: Or8a1tm41(Drd1)Mom
Name: olfactory receptor family 8 subfamily A member 1; targeted mutation 41, Peter Mombaerts
MGI ID: MGI:5616561
Synonyms: Drd1a- >M71-IRES-tauGFP
Gene: Or8a1  Location: Chr9:37641273-37642357 bp, - strand  Genetic Position: Chr9, 20.8 cM
Alliance: Or8a1tm41(Drd1)Mom page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:260975
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Or8a1tm41(Drd1)Mom expresses 1 gene
 
Mutation detailsThe endogenous coding sequence was entirely replaced with the sequence encoding amino acids 1-446 of Drd1 and an IRES-tauGFP reporter cassette along with the self-excising ACNf selection cassette, so that this allele bicistronically expresses Drd1 and the tauGFP reporter. (J:260975)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Or8a1 Mutation:  69 strains or lines available
References
Original:  J:260975 Katidou M, et al., G-protein coupled receptors Mc4r and Drd1a can serve as surrogate odorant receptors in mouse olfactory sensory neurons. Mol Cell Neurosci. 2018 Apr;88:138-147
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory