About   Help   FAQ
Sncatm1.1Vlb
Targeted Allele Detail
Nomenclature
Symbol: Sncatm1.1Vlb
Name: synuclein, alpha; targeted mutation 1.1, Vladimir L Buchman
MGI ID: MGI:5614654
Synonyms: SCNAfloxdeltaneo, Sncaflox
Gene: Snca  Location: Chr6:60708559-60806839 bp, - strand  Genetic Position: Chr6, 29.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:227400
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector containing a FRT site-flanked neo cassette and a loxP site was inserted downstream of exon 2 (the first coding exon) of the targeted gene, and another loxP site was inserted upstream of exon 2. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 2 floxed. (J:227400)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Snca Mutation:  25 strains or lines available
References
Original:  J:227400 Ninkina N, et al., A novel resource for studying function and dysfunction of alpha-synuclein: mouse lines for modulation of endogenous Snca gene expression. Sci Rep. 2015;5:16615
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/23/2021
MGI 6.17
The Jackson Laboratory