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Aars1tm1.1Slac
Targeted Allele Detail
Summary
Symbol: Aars1tm1.1Slac
Name: alanyl-tRNA synthetase 1; targeted mutation 1.1, Susan L Ackerman
MGI ID: MGI:5614439
Gene: Aars1  Location: Chr8:111759781-111784237 bp, + strand  Genetic Position: Chr8, 57.9 cM
Alliance: Aars1tm1.1Slac page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216802
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  B6(Cg)-Tyrc-2J/J
Mutation
description
Allele Type:    Targeted (Hypomorph, Inducible)
Inducer:    not specified
Mutation:    Nucleotide substitutions
 
Mutation detailsCre-excision of the loxP-flanked stop-neo cassette in the tm1Slac allele results in active expression of this hypomorph with a TGT to GCG substitution that results in the substitution of Cysteine to Alanine at amino acid 723. (J:216802)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aars1 Mutation:  68 strains or lines available
References
Original:  J:216802 Liu Y, et al., Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17570-5
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory