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Arfgef3tm1Hong
Targeted Allele Detail
Nomenclature
Symbol: Arfgef3tm1Hong
Name: ARFGEF family member 3; targeted mutation 1, Wanjin Hong
MGI ID: MGI:5614350
Gene: Arfgef3  Location: Chr10:18588011-18743758 bp, - strand  Genetic Position: Chr10, 7.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216529
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 12. Western blot analysis confirmed the absence of protein expression in the brain and islet. (J:216529)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Arfgef3 Mutation:  2 strains or lines available
References
Original:  J:216529 Li H, et al., BIG3 inhibits insulin granule biogenesis and insulin secretion. EMBO Rep. 2014 Jun;15(6):714-22
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory