Gnai2^tm2.1Rneu
Targeted Allele Detail

Summary

• Symbol: Gnai2^tm2.1Rneu
• Name: G protein subunit alpha i2; targeted mutation 2.1, Richard R Neubig
• MGI ID: MGI:5614236
• Synonyms: Galphai2^fl-G184S
• Gene: Gnai2 Location: Chr9:107491324-107512542 bp, - strand Genetic Position: Chr9, 58.43 cM
• Alliance: Gnai2^tm2.1Rneu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:217517
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 5-9 of the gene are flanked by loxP sites and followed downstream by an additional copy of exon 5 carrying a G184S mutation. An FRT-flanked neomycin resistance cassette was placed 3'. FLP mediated recombination removed the FRT-flanked neo cassette. (J:217517)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gnai2 Mutation: 54 strains or lines available

References

• Original: J:217517 Parra S, et al., Conditional disruption of interactions between Galphai2 and regulator of G protein signaling (RGS) proteins protects the heart from ischemic injury. BMC Pharmacol Toxicol. 2014;15:29
• All: 1 reference(s)