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Mex3ctm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Mex3ctm1Aki
Name: mex3 RNA binding family member C; targeted mutation 1, Shizuo Akira
MGI ID: MGI:5613894
Gene: Mex3c  Location: Chr18:73573044-73592575 bp, + strand  Genetic Position: Chr18, 49.29 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:208870
Parent Cell Line:  GSI-1 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exon 2 was replaced a neo cassette in the opposite orientation via homologous recombination. (J:208870)
Generation of the Mex3ctm1Aki mice
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mex3c Mutation:  2 strains or lines available
References
Original:  J:208870 Kuniyoshi K, et al., Pivotal role of RNA-binding E3 ubiquitin ligase MEX3C in RIG-I-mediated antiviral innate immunity. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5646-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory