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Tshbtm1Hru
Targeted Allele Detail
Nomenclature
Symbol: Tshbtm1Hru
Name: thyroid stimulating hormone, beta subunit; targeted mutation 1, Hiroki R Ueda
MGI ID: MGI:5613811
Synonyms: TSHbetaLuc
Gene: Tshb  Location: Chr3:102775465-102782718 bp, - strand  Genetic Position: Chr3, 45.25 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:214030
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA firefly luciferase cassette and floxed neomycin resistance cassette replaced the coding sequence in exon 4. QRT-PCR confirmed the absence of transcript expression in the pituitary. (J:214030)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tshb Mutation:  12 strains or lines available
References
Original:  J:214030 Tsujino K, et al., Establishment of TSH beta real-time monitoring system in mammalian photoperiodism. Genes Cells. 2013 Jul;18(7):575-88
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/14/2019
MGI 6.14
The Jackson Laboratory