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Cryba1tm1.1Dbsa
Targeted Allele Detail
Nomenclature
Symbol: Cryba1tm1.1Dbsa
Name: crystallin, beta A1; targeted mutation 1.1, Debasish Sinha
MGI ID: MGI:5613243
Synonyms: Cryba1fl
Gene: Cryba1  Location: Chr11:77718615-77725283 bp, - strand  Genetic Position: Chr11, 46.74 cM, cytoband B-C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:215856
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 and 5 were floxed. Flp-mediated recombination removed the neomycin selection cassette inserted downstream of exon 5. (J:215856)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cryba1 Mutation:  7 strains or lines available
References
Original:  J:215856 Valapala M, et al., Impaired endolysosomal function disrupts Notch signalling in optic nerve astrocytes. Nat Commun. 2013;4:1629
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory