Rpgr^tm1.1Sgj
Targeted Allele Detail

Summary

• Symbol: Rpgr^tm1.1Sgj
• Name: retinitis pigmentosa GTPase regulator; targeted mutation 1.1, Samuel G Jacobson
• MGI ID: MGI:5610131
• Gene: Rpgr Location: ChrX:10024455-10083034 bp, - strand Genetic Position: ChrX, 4.62 cM
• Alliance: Rpgr^tm1.1Sgj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213970
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site inserted upstream of exon 1. A floxed neomycin resistance cassette inserted downstream of exon 1. Cre-mediated recombination removed exon 1 and the selection cassette. (J:213970)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rpgr Mutation: 8 strains or lines available

References

• Original: J:213970 Huang WC, et al., RPGR-associated retinal degeneration in human X-linked RP and a murine model. Invest Ophthalmol Vis Sci. 2012;53(9):5594-608
• All: 3 reference(s)