Pde10a^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Pde10a^tm1Dgen
• Name: phosphodiesterase 10A; targeted mutation 1, Deltagen
• MGI ID: MGI:5610034
• Gene: Pde10a Location: Chr17:8744204-9205480 bp, + strand Genetic Position: Chr17, 4.96 cM
• Alliance: Pde10a^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216851
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ Neo cassette was inserted by homologous recombination to delete a 53 bp fragment from base 1819 to 1871. (J:216851)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde10a Mutation: 60 strains or lines available

References

• Original: J:216851 Piccart E, et al., Genetic deletion of PDE10A selectively impairs incentive salience attribution and decreases medium spiny neuron excitability. Behav Brain Res. 2014 Jul 15;268:48-54
• All: 1 reference(s)