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Sik2tm1Htake
Targeted Allele Detail
Nomenclature
Symbol: Sik2tm1Htake
Name: salt inducible kinase 2; targeted mutation 1, Hiroshi Takemori
MGI ID: MGI:5609867
Gene: Sik2  Location: Chr9:50892801-51009073 bp, - strand  Genetic Position: Chr9, 27.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:215877
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression in white and brown adipose tissues. (J:215877)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sik2 Mutation:  29 strains or lines available
References
Original:  J:215877 Horike N, et al., Downregulation of SIK2 expression promotes the melanogenic program in mice. Pigment Cell Melanoma Res. 2010 Dec;23(6):809-19
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory