Ptprc^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Ptprc^m2Btlr
• Name: protein tyrosine phosphatase receptor type C; mutation 2, Bruce Beutler
• MGI ID: MGI:5609786
• Synonyms: guotie
• Gene: Ptprc Location: Chr1:137990599-138103446 bp, - strand Genetic Position: Chr1, 60.73 cM
• Alliance: Ptprc^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Applicable)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is a C-to-T transition at base pair 138,068,401 (GRCm38) on chromosome 1, or base pair 110,989 in the GenBank genomic region NC_000067. This corresponds to nucleotide 3,658 in the mRNA sequence NM_001111316, within exon 33 of 33 total exons; residue 3,339 in the mRNA sequence NM_011210, within exon 30 of 30 total exons; and residue 3,267 in the mRNA sequence NM_001268286, within exon 29 of 29 total exons. The mutation results in conversion of a codon for glutamine (Q) 1212 (isoform 1), Q1068 (isoform 2), or Q1047 (isoform 3) of the CD45 protein to a stop codon (Ter) (p.Q1212*/p.Q1068*/p.Q1047*). (J:216796)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptprc Mutation: 188 strains or lines available

References

• Original: J:216796 Zeng M, et al., Mutagenetix entry for guotie. Updated January 09, 2015. MGI Direct Data Submission. 2015
• All: 2 reference(s)