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Abcc2tm1.1(ABCC2)Arte
Targeted Allele Detail
Summary
Symbol: Abcc2tm1.1(ABCC2)Arte
Name: ATP-binding cassette, sub-family member 2; targeted mutation 1.1, TaconicArtemis
MGI ID: MGI:5609256
Synonyms: hMRP2, huMRP2
Gene: Abcc2  Location: Chr19:43770747-43826771 bp, + strand  Genetic Position: Chr19, 36.67 cM
Alliance: Abcc2tm1.1(ABCC2)Arte page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216646
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Abcc2tm1.1(ABCC2)Arte expresses 1 gene
 
Mutation detailsExon 2 was replaced with a cDNA containing human ABCC2 exons 2-32 and a polyA signal and a neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. Quantitative PCR analysis confirmed absence of expression of the mouse gene and stable expression of the human gene in the liver kidney and intestines of homozygous mice. Expression levels of the human gene are elevated compared to expression levels of the mouse gene. Western blot analysis confirmed the expression of the human protein and absence of the mouse protein in the liver, kidney and intestines from homozygous mice. (J:216646)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc2 Mutation:  90 strains or lines available
References
Original:  J:216646 Scheer N, et al., Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line. Drug Metab Dispos. 2012 Nov;40(11):2212-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory