Prf1^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Prf1^m1Btlr
• Name: perforin 1 (pore forming protein); mutation 1, Bruce Beutler
• MGI ID: MGI:5607639
• Synonyms: prime
• Gene: Prf1 Location: Chr10:61133612-61140459 bp, + strand Genetic Position: Chr10, 32.18 cM
• Alliance: Prf1^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details: The molecular lesion is a C to A transversion at base pair 61,303,722 (v38) on chromosome 10, or base pair 6,045 in the GenBank genomic region NC_000076. This corresponds to nucleotide 1,513 in the mRNA sequence NM_011073, within exon 3 of 3 total exons. The mutation results in substitution of a premature stop codon for a tyrosine at residue 486 (Y486Ter). (J:216044)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prf1 Mutation: 48 strains or lines available

References

• Original: J:216044 Zhang D, et al., Mutagenetix entry for prime. Updated on December 15, 2014. MGI Direct Data Submission. 2014
• All: 1 reference(s)