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Cnot3tm1.1Tya
Targeted Allele Detail
Nomenclature
Symbol: Cnot3tm1.1Tya
Name: CCR4-NOT transcription complex, subunit 3; targeted mutation 1.1, Tadashi Yamamoto
MGI ID: MGI:5607530
Synonyms: Cnot3-
Gene: Cnot3  Location: Chr7:3645268-3661109 bp, + strand  Genetic Position: Chr7, 2.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:180033
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette flanked by two loxP sites was inserted in the intron preceding exon 2 and another loxP site was inserted following exon 9. Both the PGK-neo cassette and exons 2-9 were removed via cre-mediated recombination. (J:180033)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cnot3 Mutation:  17 strains or lines available
References
Original:  J:180033 Morita M, et al., Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3+/- mice. EMBO J. 2011 Nov 16;30(22):4678-91
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory