Cdk1^tm1Eddy
Targeted Allele Detail

Summary

• Symbol: Cdk1^tm1Eddy
• Name: cyclin dependent kinase 1; targeted mutation 1, Edward M Eddy
• MGI ID: MGI:5604426
• Synonyms: Cdk1^flox, Cdk1^L
• Gene: Cdk1 Location: Chr10:69170976-69188742 bp, - strand Genetic Position: Chr10, 36.07 cM
• Alliance: Cdk1^tm1Eddy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214812
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted flanking exon 3 and a neomycin gene flanked by FRT sites was inserted into intron 2. (J:214812)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdk1 Mutation: 21 strains or lines available

References

• Original: J:214812 Chaffee BR, et al., Nuclear removal during terminal lens fiber cell differentiation requires CDK1 activity: appropriating mitosis-related nuclear disassembly. Development. 2014 Sep;141(17):3388-98
• All: 5 reference(s)