Tshz1^tm2.1Garr
Targeted Allele Detail

Summary

• Symbol: Tshz1^tm2.1Garr
• Name: teashirt zinc finger family member 1; targeted mutation 2.1, Alistair N Garratt
• MGI ID: MGI:5588816
• Synonyms: Tshz1^flox
• Gene: Tshz1 Location: Chr18:84029752-84105831 bp, - strand Genetic Position: Chr18, 57.53 cM
• Alliance: Tshz1^tm2.1Garr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209428
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and a single frt site were inserted into intron upstream of exon2, and another loxP site was inserted into intron downstream of exon2 of Tshz1 gene. This allele was generated by crossing Tshz1^tm2Garr chimera mice with mice carrying the Flp-e deleter allele Tg(ACTFLPe)9205Dym to remove neo-cassette. (J:209428)

Expression

In Mice Carrying this Mutation:	154 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tshz1 Mutation: 51 strains or lines available

References

• Original: J:209428 Ragancokova D, et al., TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction. J Clin Invest. 2014 Mar 3;124(3):1214-27
• All: 3 reference(s)