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Tshz1tm1Garr
Targeted Allele Detail
Nomenclature
Symbol: Tshz1tm1Garr
Name: teashirt zinc finger family member 1; targeted mutation 1, Alistair N Garratt
MGI ID: MGI:5588813
Synonyms: Tshz1GFP
Gene: Tshz1  Location: Chr18:84011627-84086562 bp, - strand  Genetic Position: Chr18, 57.53 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:209428
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA GAP43-EGFP cassette and a self-excision cre-neomycin cassette (SEcre Neo) was fused in-frame following the first five codon of exon2 while removing most of the open reading frame of Tshz1 gene by homologous recombination. SEcre Neo cassette was removed in chimera male germline leaving fusion protein contains the first 18 amino acids of TSHZ1 (ending in YVPE encoded at the start of exon 2), followed by the N-terminal 23 amino acids of GAP43 and EGFP sequences, ending with the termination codon of EGFP. The in situ hybridization and immunostaining on homozygous embryos confirmed absence of transcripts and functional protein products. This is a null allele. (J:209428)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tshz1 Mutation:  0 strains or lines available
References
Original:  J:209428 Ragancokova D, et al., TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction. J Clin Invest. 2014 Mar 3;124(3):1214-27
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory