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Ano1tm1.2Cahb
Targeted Allele Detail
Nomenclature
Symbol: Ano1tm1.2Cahb
Name: anoctamin 1, calcium activated chloride channel; targeted mutation 1.2, Christian Hubner
MGI ID: MGI:5588154
Gene: Ano1  Location: Chr7:144588549-144751974 bp, - strand  Genetic Position: Chr7, 88.85 cM
Abnormal tracheal cartilages in Ano1tm1.2Cahb/Ano1tm1.2Cahb mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:207993
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exon 21 was floxed. Cre-mediated recombination removed the neomycin resistance cassette and exon 21. (J:207993)
Generation of the Ano1tm1.1Cahb and Ano1tm1.2Cahb alleles
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ano1 Mutation:  5 strains or lines available
References
Original:  J:207993 Heinze C, et al., Disruption of vascular Ca2+-activated chloride currents lowers blood pressure. J Clin Invest. 2014 Feb 3;124(2):675-86
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory