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Insctm1.2Cayo
Targeted Allele Detail
Summary
Symbol: Insctm1.2Cayo
Name: INSC spindle orientation adaptor protein; targeted mutation 1.2, Michel Cayouette
MGI ID: MGI:5588153
Synonyms: mInscDEL
Gene: Insc  Location: Chr7:114342931-114449615 bp, + strand  Genetic Position: Chr7, 60.23 cM
Alliance: Insctm1.2Cayo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:214064
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated excision of 82 kb of sequence beginning after exon 1b and ending after exon 13, just beforethe IRES-tau-EGFP cassette, produced this knockout reporter. Immunohistochemistry for both the long and short isoforms failed to detect protein product in cochlear hair cells of homozygotes. (J:214064)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Insc Mutation:  30 strains or lines available
References
Original:  J:214064 Tarchini B, et al., A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells. Dev Cell. 2013 Oct 14;27(1):88-102
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory