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Cpeb4tm1.1Yshu
Targeted Allele Detail
Nomenclature
Symbol: Cpeb4tm1.1Yshu
Name: cytoplasmic polyadenylation element binding protein 4; targeted mutation 1.1, Yi-Shuian Huang
MGI ID: MGI:5587820
Gene: Cpeb4  Location: Chr11:31872211-31935634 bp, + strand  Genetic Position: Chr11, 18.66 cM
Slight increase in dendritic spine length in Cpeb4tm1.1Yshu/Cpeb4tm1.1Yshu neurons

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:209837
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette with a 3 loxP site was inserted downstream of exon 2. Cre-mediated recombination removed exon 2 and the selection cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:209837)
Generation of the Cpeb4tm1.1Yshu allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpeb4 Mutation:  3 strains or lines available
References
Original:  J:209837 Tsai LY, et al., CPEB4 knockout mice exhibit normal hippocampus-related synaptic plasticity and memory. PLoS One. 2013;8(12):e84978
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory