About   Help   FAQ
Gt(ROSA)26Sortm1(Sirt1)Ktm
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(Sirt1)Ktm
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Tadahiro Kitamura
MGI ID: MGI:5586718
Synonyms: Rosa26Sirt1-WT
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:209418
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(Sirt1)Ktm expresses 1 gene
 
Mutation detailsA targeting construct introduced into the locus a splice acceptor, floxed neomycin resistance/STOP cassette and cDNA. (J:209418)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  504 strains or lines available
References
Original:  J:209418 Sasaki T, et al., Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice. Diabetologia. 2014 Apr;57(4):819-31
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/03/2019
MGI 6.14
The Jackson Laboratory