Oprm1^tm1.1Jbwa
Targeted Allele Detail

Summary

• Symbol: Oprm1^tm1.1Jbwa
• Name: opioid receptor, mu 1; targeted mutation 1.1, Jia Bei Wang
• MGI ID: MGI:5586574
• Synonyms: MOR KI, T394A
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^tm1.1Jbwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A targeting construct was designed to insert a loxP and frt-flanked neomycin (neo) resistance cassette downstream of exon 4 of the opioid receptor, mu 1 (Oprm1) gene. An A to G point mutation was introduced in exon 4, resulting in the amino acid mutation T394A. Flp-mediated recombination removed the FRT-flanked neomycin cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 53 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 2 reference(s)