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Col1a1tm3(tetO-Fosl1,-DsRed)Wag
Targeted Allele Detail
Summary
Symbol: Col1a1tm3(tetO-Fosl1,-DsRed)Wag
Name: collagen, type I, alpha 1; targeted mutation 3, Erwin F Wagner
MGI ID: MGI:5585716
Synonyms: tet-O-Fosl1, tet-O-Fra1
Gene: Col1a1  Location: Chr11:94827050-94843868 bp, + strand  Genetic Position: Chr11, 59.01 cM, cytoband D
Alliance: Col1a1tm3(tetO-Fosl1,-DsRed)Wag page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:213764
Parent Cell Line:  KH2 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Inducible, Inserted expressed sequence, RMCE-ready, Reporter)
Inducer:    doxycycline/tetracycline
Mutation:    Insertion
 
Col1a1tm3(tetO-Fosl1,-DsRed)Wag expresses 1 gene
 
Mutation detailsKH2 ES cells were retargeted with a "flp-in plasmid containing a tetracycline responsive element (TRE or tetO), FLAG-tagged Fosl1 cDNA sequence, GtX IRES sequence and DsRed reporter. A flpe-recombinase plasmid facilitated integration into the 3' UTR region. (J:213764)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col1a1 Mutation:  160 strains or lines available
Notes
The allele was made in KH2 cells that carry Gt(ROSA)26Sortm1(rtTA*M2)Jae and Col1a1tm13(neo/hygro*)Jae (J:159351). This allele was generated with Col1a1tm13(neo/hygro*)Jae.
References
Original:  J:213764 Hasenfuss SC, et al., Activator Protein 1 transcription factor Fos-related antigen 1 (Fra-1) is dispensable for murine liver fibrosis, but modulates xenobiotic metabolism. Hepatology. 2014 Jan;59(1):261-73
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory