Endou^tm1Tft
Targeted Allele Detail

Summary

• Symbol: Endou^tm1Tft
• Name: endonuclease, polyU-specific; targeted mutation 1, Thomas F Tedder
• MGI ID: MGI:5582894
• Gene: Endou Location: Chr15:97608896-97629220 bp, - strand Genetic Position: Chr15, 53.7 cM
• Alliance: Endou^tm1Tft page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:208364
• Parent Cell Line: EF1 (ES Cell)
• Strain of Origin: 129S/SvEv x C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced the distal portion of exon 4. Western blot analysis confirmed the absence of protein expression. (J:208364)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Endou Mutation: 28 strains or lines available

References

• Original: J:208364 Poe JC, et al., EndoU is a novel regulator of AICD during peripheral B cell selection. J Exp Med. 2014 Jan 13;211(1):57-69
• All: 1 reference(s)