Clec4n^tm1.2Mgne
Targeted Allele Detail

Summary

• Symbol: Clec4n^tm1.2Mgne
• Name: C-type lectin domain family 4, member n; targeted mutation 1.2, Mihai G Netea
• MGI ID: MGI:5582826
• Gene: Clec4n Location: Chr6:123206802-123223980 bp, + strand Genetic Position: Chr6, 58.3 cM, cytoband F3
• Alliance: Clec4n^tm1.2Mgne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209284
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Inversion
• Mutation details: A lox66 was inserted upstream of exon 2. An inverted STOP element and lox71 site was inserted downstream of exon 2. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted between exon 2 and 3. Cre-mediated recombination restores the orientation of the STOP element and inverts exon 2. (J:209284)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec4n Mutation: 25 strains or lines available

References

• Original: J:209284 Ifrim DC, et al., Role of Dectin-2 for host defense against systemic infection with Candida glabrata. Infect Immun. 2014 Mar;82(3):1064-73
• All: 4 reference(s)