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F8tm1.1Rmnt
Targeted Allele Detail
Nomenclature
Symbol: F8tm1.1Rmnt
Name: coagulation factor VIII; targeted mutation 1.1, Robert Montgomery
MGI ID: MGI:5582808
Synonyms: F8F
Gene: F8  Location: ChrX:74216321-74426221 bp, - strand  Genetic Position: ChrX, 38.17 cM, cytoband A7-B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212401
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExons 17 and 18 and FRT-flanked neo cassette were flanked by two loxP sites. FLP-mediated recombinase removed the neo cassette, leaving exons 17 and 18 floxed. (J:212401)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any F8 Mutation:  20 strains or lines available
References
Original:  J:212401 Fahs SA, et al., A conditional knockout mouse model reveals endothelial cells as the principal and possibly exclusive source of plasma factor VIII. Blood. 2014 Jun 12;123(24):3706-13
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory