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Keltm1Slee
Targeted Allele Detail
Summary
Symbol: Keltm1Slee
Name: Kell blood group; targeted mutation 1, Soohee Lee
MGI ID: MGI:5581644
Gene: Kel  Location: Chr6:41663263-41681268 bp, - strand  Genetic Position: Chr6, 19.86 cM
Alliance: Keltm1Slee page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212529
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA 3.2 kb segment spanning from the start of exon 11 into exon 16. This region includes the zinc binding enzymatically active site was reolaced with a neomycin resistance gene. Northern blot analysis confirmed the absence of mRNA and Western blot analysis demonstrated the absence of protein on RBC membranes. (J:212529)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kel Mutation:  33 strains or lines available
References
Original:  J:212529 Zhu X, et al., Changes in red cell ion transport, reduced intratumoral neovascularization, and some mild motor function abnormalities accompany targeted disruption of the Mouse Kell gene (Kel). Am J Hematol. 2009 Aug;84(8):492-8
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory