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Targeted Allele Detail
Symbol: Prg4tm2Mawa
Name: proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein); targeted mutation 2, Matthew Warman
MGI ID: MGI:5581510
Synonyms: Prg4GT, Prg4:GT
Gene: Prg4  Location: Chr1:150325163-150341916 bp, - strand  Genetic Position: Chr1, 63.84 cM, cytoband G
Germline Transmission:  Earliest citation of germline transmission: J:101977
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Null/knockout, Reporter, Transactivator)
Mutation:    Insertion
Mutation detailsA targeting vector containing a loxP-flanked artifical exon that contains a strong splice acceptor, an in-frame Bgeo lacZ coding sequence, an internal ribosome entry site (IRES), a reverse tet transactivator (rtTA) cassette with a polyA signal, and a neomycin selection cassette driven by its own promoter was inserted into intron 2 of the gene. The allele does not express wild-type Prg4 mRNA, as determined by RT-PCR. Cre-mediated excision of the targeting vector leaves one loxP in intron 2 and allows expression of Prg4 mRNA. (J:101977)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prg4 Mutation:  43 strains or lines available
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
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