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Dnase1l3tm1Dkit
Targeted Allele Detail
Summary
Symbol: Dnase1l3tm1Dkit
Name: deoxyribonuclease 1-like 3; targeted mutation 1, Daisuke Kitamura
MGI ID: MGI:5581508
Synonyms: DNase gamma -
Gene: Dnase1l3  Location: Chr14:14475014-14504586 bp, + strand  Genetic Position: Chr14, 4.67 cM, cytoband A1
Alliance: Dnase1l3tm1Dkit page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:211019
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced codon His160 in exon 5, which comprises the catalytic center of the endonuclease. An activity gel assay confirmed the absence of protein activity. (J:211019)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dnase1l3 Mutation:  16 strains or lines available
References
Original:  J:211019 Mizuta R, et al., DNase gamma is the effector endonuclease for internucleosomal DNA fragmentation in necrosis. PLoS One. 2013;8(12):e80223
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory