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Targeted Allele Detail
Symbol: Cgastm1d(EUCOMM)Hmgu
Name: cyclic GMP-AMP synthase; targeted mutation 1d, Helmholtz Zentrum Muenchen GmbH
MGI ID: MGI:5578170
Synonyms: cGAS, Mb21d1-
Gene: Cgas  Location: Chr9:78430526-78443237 bp, - strand  Genetic Position: Chr9, 43.65 cM
Mutant Cell Line:  HEPD0516_3_C04
Germline Transmission:  Earliest citation of germline transmission: J:207826
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 78437955 of Chromosome 9 upstream of the critical exon 2 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 2 at position 78437075. The critical exon 2 is thus flanked by loxP sites. Flp-mediated recombination removed the beta-geo cassette and left exon 2 floxed. Cre-mediated recombination removed exon 2. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:207826)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cgas Mutation:  15 strains or lines available
Original:  J:207826 Schoggins JW, et al., Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Nature. 2014 Jan 30;505(7485):691-5
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory