Idh2^tm1Jwpk
Targeted Allele Detail

Summary

• Symbol: Idh2^tm1Jwpk
• Name: isocitrate dehydrogenase 2 (NADP+), mitochondrial; targeted mutation 1, Jeen-Woo Park
• MGI ID: MGI:5578147
• Gene: Idh2 Location: Chr7:79744594-79765140 bp, - strand Genetic Position: Chr7, 45.43 cM
• Alliance: Idh2^tm1Jwpk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210036
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neomycin resistance cassette replaced exon 1. Western blot analysis confirmed the absence of protein expression. (J:210036)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Idh2 Mutation: 146 strains or lines available

References

• Original: J:210036 Kim S, et al., Suppression of tumorigenesis in mitochondrial NADP(+)-dependent isocitrate dehydrogenase knock-out mice. Biochim Biophys Acta. 2014 Feb;1842(2):135-43
• All: 18 reference(s)