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Tg(Thy1-FUS*)19Vlb
Transgene Detail
Nomenclature
Symbol: Tg(Thy1-FUS*)19Vlb
Name: transgene insertion 19, Vladimir L Buchman
MGI ID: MGI:5577178
Synonyms: FUS-TG
Transgene: Tg(Thy1-FUS*)19Vlb  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x CBA
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of a fragment of human FUS 1-359 cDNA including 9 bp of 5'-UTR under the control of the Thy1 promoter. This FUS variant is predominantly cytoplasmic as it lacks the nuclear localization signal, highly aggregate-prone, and lacks a region responsible for RNA recognition and binding. Western blot confirmed expression in neural tissues. (J:203550)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:203550 Shelkovnikova TA, et al., Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice. J Biol Chem. 2013 Aug 30;288(35):25266-74
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory