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Tg(Myh6-TNNT2*R141W)#Lian
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-TNNT2*R141W)#Lian
Name: transgene insertion, Zhang Lianfeng
MGI ID: MGI:5576170
Synonyms: cTnTR141W
Transgene: Tg(Myh6-TNNT2*R141W)#Lian  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-TNNT2*R141W)#Lian expresses 1 gene
 
Mutation detailsThis transgene consists of the Myh6 promoter driving expression of a full-length human TNNT2 cDNA containing a T to C substitution at position 520 that results in the R141W mutation. Northern blot and immunohistochemistry confirmed expression. Three lines were established: 1, 13, and 16, however the pound symbol (#) is used because the lines are pooled. (J:211769)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Three lines were established: 1, 13, and 16.
References
Original:  J:211769 Juan F, et al., The changes of the cardiac structure and function in cTnTR141W transgenic mice. Int J Cardiol. 2008 Aug 1;128(1):83-90
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory