About   Help   FAQ
Asxl1tm1.1Mjxu
Targeted Allele Detail
Nomenclature
Symbol: Asxl1tm1.1Mjxu
Name: additional sex combs like 1; targeted mutation 1.1, Mingjiang Xu
MGI ID: MGI:5575668
Synonyms: Asxl1:nlacZ/nGFP
Gene: Asxl1  Location: Chr2:153345830-153404007 bp, + strand  Genetic Position: Chr2, 75.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:208085
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsPart of exon 1 was replaced with a loxP site, nuclear localized lacZ reporter, loxP site, nuclear localized GFP (H2B-GFP) reporter and FRT-flanked neomycin resistance cassette. Flp-mediated recombination removed the selection cassette. Western blot analysis confirmed the absence of protein expression in bone marrow cells. (J:208085)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Asxl1 Mutation:  104 strains or lines available
References
Original:  J:208085 Wang J, et al., Loss of Asxl1 leads to myelodysplastic syndrome-like disease in mice. Blood. 2014 Jan 23;123(4):541-53
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/03/2019
MGI 6.14
The Jackson Laboratory