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Tg(Prnp-SNAP25/HTT*150Q)8Xjl
Transgene Detail
Nomenclature
Symbol: Tg(Prnp-SNAP25/HTT*150Q)8Xjl
Name: transgene insertion 8, Xiao-Jiang Li
MGI ID: MGI:5575507
Synonyms: SNAP25-150Q
Transgene: Tg(Prnp-SNAP25/HTT*150Q)8Xjl  Location: unknown  
Appearance of old Tg(Prnp-SNAP25/HTT*150Q)8Xjl/0 (150Q) mouse and control littermate at 13 months of age

Show the 2 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Prnp-SNAP25/HTT*150Q)8Xjl expresses 1 gene
 
Mutation detailsExon 1 of HTT containing 150 CAG repeats (150Q) was fused to the C terminus of SNAP25 and is under the control of the mouse prion promoter. Three lines were established: 2, 8, and 15. (J:201806)
Schematic of the Tg(Prnp-SNAP25/HTT*150Q)8Xjl transgene
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:201806 Xu Q, et al., Synaptic mutant huntingtin inhibits synapsin-1 phosphorylation and causes neurological symptoms. J Cell Biol. 2013 Sep 30;202(7):1123-38
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory