Dlx2^tm1.1Rth
Targeted Allele Detail

Summary

• Symbol: Dlx2^tm1.1Rth
• Name: distal-less homeobox 2; targeted mutation 1.1, David H Rowitch
• MGI ID: MGI:5575409
• Synonyms: Dlx1/Dlx2^tm1.1Rth
• Gene: Dlx2 Location: Chr2:71373752-71377095 bp, - strand Genetic Position: Chr2, 42.65 cM
• Alliance: Dlx2^tm1.1Rth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212992
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (C57BL/6 x 129S/SvEv)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT-flanked PGK-neomycin cassette and loxP site were placed in intron 1. Flp-mediated recombination removed the selection cassette. (J:212992)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dlx2 Mutation: 25 strains or lines available

Notes

This allele was generated in ES cells in conjunction with Dlx1^tm1Rth.

References

• Original: J:212992 Silbereis JC, et al., Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron. 2014 Feb 5;81(3):574-87
• All: 5 reference(s)