Adcy3^Jll
Chemically induced Allele Detail

Summary

• Symbol: Adcy3^Jll
• Name: adenylate cyclase 3; Jll
• MGI ID: MGI:5574448
• Synonyms: Adcy3^Jll-Gek, Adcy3^M279I
• Gene: Adcy3 Location: Chr12:4183397-4263525 bp, + strand Genetic Position: Chr12, 1.99 cM, cytoband A-B
• Alliance: Adcy3^Jll page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a G to A transition that results in the amino acid substitution of methionine-to-isoleucine at position 279 (M279I). (J:223554)
• Inheritance: Dominant

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adcy3 Mutation: 42 strains or lines available

References

• Original: J:223554 Pitman JL, et al., A gain-of-function mutation in adenylate cyclase 3 protects mice from diet-induced obesity. PLoS One. 2014;9(10):e110226
• All: 1 reference(s)