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Diaph3tm1.1Sna
Targeted Allele Detail
Nomenclature
Symbol: Diaph3tm1.1Sna
Name: diaphanous related formin 3; targeted mutation 1.1, Shuh Narumiya
MGI ID: MGI:5574347
Gene: Diaph3  Location: Chr14:86892803-87378671 bp, - strand  Genetic Position: Chr14, 43.95 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:205519
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsOne loxP site was inserted upstream of exon1 and a floxed neomycin resistance cassette was inserted downstream. Exon 1 was subsequently removed by cre excision. (J:205519)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Diaph3 Mutation:  67 strains or lines available
References
Original:  J:205519 Watanabe S, et al., Loss of a Rho-regulated actin nucleator, mDia2, impairs cytokinesis during mouse fetal erythropoiesis. Cell Rep. 2013 Nov 27;5(4):926-32
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/27/2022
MGI 6.21
The Jackson Laboratory