Grin1^tm1Jjwd
Targeted Allele Detail

Summary

• Symbol: Grin1^tm1Jjwd
• Name: glutamate receptor, ionotropic, NMDA1 (zeta 1); targeted mutation 1, John J Woodward
• MGI ID: MGI:5574216
• Synonyms: GluN1^A, GluN1^F639A
• Gene: Grin1 Location: Chr2:25181193-25209199 bp, - strand Genetic Position: Chr2, 17.14 cM
• Alliance: Grin1^tm1Jjwd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209690
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 16 was replaced with a modified exon 16 in which nucleotide substitutions result in the amino acid substitution of alanine for phenylalanine at position 639 (F639A). A floxed neomycin resistance cassette was inserted downstream of exon 18. (J:209690)

Generation of the Grin1^tm1Jjwd allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin1 Mutation: 64 strains or lines available

References

• Original: J:209690 den Hartog CR, et al., Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors. PLoS One. 2013;8(11):e80541
• All: 2 reference(s)