Tg(Cnp-MAPT*P301L)6Vle
Transgene Detail

Summary

• Symbol: Tg(Cnp-MAPT*P301L)6Vle
• Name: transgene insertion 6, Virginia M Y Lee
• MGI ID: MGI:5573156
• Synonyms: Tau CNP Tg
• Transgene: Tg(Cnp-MAPT*P301L)6Vle Location: unknown
• Alliance: Tg(Cnp-MAPT*P301L)6Vle page

Transgene origin

• Strain of Origin: (C57BL/6 x C3H)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The murine 2', 3'-cyclic nucleotide 3'-phosphodiesterase promoter drives expression of the P301L mutant human microtubule-associated protein tau, MAPT. Immunohistochemistry confirmed expression in oligodendrocytes. (J:127923)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:127923 Giasson BI, et al., Initiation and synergistic fibrillization of tau and alpha-synuclein. Science. 2003 Apr 25;300(5619):636-40
• All: 1 reference(s)