Tnfrsf1a^{tm4.1(TNFRSF1A)Gkl}
Targeted Allele Detail

Summary

• Symbol: Tnfrsf1a^{tm4.1(TNFRSF1A)Gkl}
• Name: tumor necrosis factor receptor superfamily, member 1a; targeted mutation 4.1, George Kollias
• MGI ID: MGI:5572951
• Synonyms: hTnfrsf1alpha KI
• Gene: Tnfrsf1a Location: Chr6:125326686-125339446 bp, + strand Genetic Position: Chr6, 59.32 cM
• Alliance: Tnfrsf1a^{tm4.1(TNFRSF1A)Gkl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210950
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

Allele Type: Targeted (Humanized sequence) Mutations: Insertion, Intragenic deletion Mutation details: The open reading frame was replaced with the corresponding human sequence. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted upstream of the human sequence. A second loxP site was inserted downstream of exon 5. (J:210950)

Generation of the Tnfrsf1a^tm4.1(TNFRSF1A)Gkl allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfrsf1a Mutation: 47 strains or lines available

References

• Original: J:210950 Van Hauwermeiren F, et al., Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium. J Clin Invest. 2013 Jun 3;123(6):2590-603
• All: 1 reference(s)