Sox2^tm1.2Lan
Targeted Allele Detail

Summary

• Symbol: Sox2^tm1.2Lan
• Name: SRY (sex determining region Y)-box 2; targeted mutation 1.2, Richard A Lang
• MGI ID: MGI:5572835
• Gene: Sox2 Location: Chr3:34704554-34706610 bp, + strand Genetic Position: Chr3, 16.93 cM, cytoband A2-B
• Alliance: Sox2^tm1.2Lan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205532
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted usptream of the coding exon and an frt flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of the exon. The frt flanked neo cassette used for selection was removed by germ line, flp mediated recombination. Cre-mediated recombination removed the coding exon. (J:205532)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox2 Mutation: 56 strains or lines available

References

• Original: J:205532 Wang S, et al., Transient activation of autophagy via Sox2-mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell. 2013 Nov 7;13(5):617-25
• All: 1 reference(s)