Derl3^tm1Kame
Targeted Allele Detail

Summary

• Symbol: Derl3^tm1Kame
• Name: Der1-like domain family, member 3; targeted mutation 1, Koichi Kokame
• MGI ID: MGI:5571585
• Gene: Derl3 Location: Chr10:75729247-75731775 bp, + strand Genetic Position: Chr10, 38.61 cM, cytoband B5.3
• Alliance: Derl3^tm1Kame page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210654
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A neomycin resistance cassette replaced exons 1 through 7. Western blot analysis confirmed the absence of protein expression in the liver, pancreas and kidney. (J:210654)

Generation of the Derl3^tm1Kame allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Derl3 Mutation: 10 strains or lines available

References

• Original: J:210654 Eura Y, et al., Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. PLoS One. 2012;7(3):e34298
• All: 2 reference(s)