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Adam17tm1.2Wesh
Targeted Allele Detail
Summary
Symbol: Adam17tm1.2Wesh
Name: a disintegrin and metallopeptidase domain 17; targeted mutation 1.2, Wei Shi
MGI ID: MGI:5571392
Gene: Adam17  Location: Chr12:21373510-21423633 bp, - strand  Genetic Position: Chr12, 8.3 cM
Alliance: Adam17tm1.2Wesh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:210193
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCre-mediated recombination removed exon 3 and the neomycin resistance cassette. Immunostaining confirmed the absence of protein expression in the lungs. (J:210193)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam17 Mutation:  62 strains or lines available
References
Original:  J:210193 Xu W, et al., TACE in perinatal mouse lung epithelial cells promotes lung saccular formation. Am J Physiol Lung Cell Mol Physiol. 2013 Dec;305(12):L953-63
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory