Runx2^tm1.1Yyon
Targeted Allele Detail

Summary

• Symbol: Runx2^tm1.1Yyon
• Name: runt related transcription factor 2; targeted mutation 1.1, Yukio Yoneda
• MGI ID: MGI:5570536
• Synonyms: Runx2(loxP)
• Gene: Runx2 Location: Chr17:44806873-45125518 bp, - strand Genetic Position: Chr17, 21.33 cM
• Alliance: Runx2^tm1.1Yyon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210124
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 4. An additional loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and left exon 4 floxed. (J:210124)

Expression

In Mice Carrying this Mutation:

1 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx2 Mutation: 42 strains or lines available

References

• Original: J:210124 Takarada T, et al., An analysis of skeletal development in osteoblast-specific and chondrocyte-specific runt-related transcription factor-2 (Runx2) knockout mice. J Bone Miner Res. 2013 Oct;28(10):2064-9
• All: 12 reference(s)