Dmd^tm1.1Know
Targeted Allele Detail

Summary

• Symbol: Dmd^tm1.1Know
• Name: dystrophin, muscular dystrophy; targeted mutation 1.1, Kirk Knowlton
• MGI ID: MGI:5569634
• Synonyms: Dys^KI
• Gene: Dmd Location: ChrX:81992476-84249747 bp, + strand Genetic Position: ChrX, 38.38 cM, cytoband C
• Alliance: Dmd^tm1.1Know page

Decreased susceptibility to coxsackievirus B3 viral infection of the heart in Dmd^tm1.1Know/Dmd^tm1.1Know mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207775
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Two point mutations in exon 50 result in the amino acid substitution of proline for lysine at position 2425 (L2425P) and aspartic acid for serine at position 2426 (S2426D). This mutations prevent cleavage by protease 2A. Cre-mediated recombination removed the floxed neomycin resistance cassette. (J:207775)

Generation of the Dmd^tm1.1Know allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmd Mutation: 153 strains or lines available

References

• Original: J:207775 Lim BK, et al., Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy. J Clin Invest. 2013 Dec 2;123(12):5146-51
• All: 2 reference(s)